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Silevertinib

CAT: 0804-HY-153268-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153268-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BDTX-1535 (EGFR-IN-76) is an orally available, blood-brain permeable, selective EGFR inhibitor with anti-tumor activity. BDTX-1535 is indicated in a variety of models including non-small cell lung cancer, glioblastoma patient-derived tumors, and intracranial tumors[1][2][3].
CAS Number
2607829-38-7
Product Name Alternative
BDTX-1535; EGFR-IN-76
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bdtx-1535.html
Purity
99.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(/C=C/CN1CCOCC1)NC2=CC3=C(N=CN=C3NC4=C(C(Cl)=CC=C4)F)C=C2C#C[C@]56[C@](CN(C6)C)([H])C5
Molecular Formula
C30H30ClFN6O2
Molecular Weight
561.05
Precautions
H302, H315, H319
References & Citations
[1]O'Connor M, et al. Discovery of BDTX-1535, a novel 4th generation, irreversible, potent, wild type sparing EGFR MasterKey inhibitor that targets oncogenic kinase domain mutations as well as extracellular domain alterations for the treatment of NSCLC and GBM[J]. Cancer Research, 2023, 83 (7_Supplement) : 3396-3396.|[2]Lucas M, et al. BDTX-1535, a fourth generation EGFR inhibitor, targeting intrinsic and acquired resistance mutations in NSCLC[J]. European Journal of Cancer, 2022, 174: S22.|[3]Lucas MC, et al. Preparation of alkynyl quinazoline compounds as anticancer agents. World Intellectual Property Organization, WO2021030711 A1. 2021-02-18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
A24178-10Silevertinib (BDTX-1535, EGFR-IN-76) 10mg
A24178-100Silevertinib (BDTX-1535, EGFR-IN-76) 100mg
A24178-50Silevertinib (BDTX-1535, EGFR-IN-76) 50mg
A24178-5Silevertinib (BDTX-1535, EGFR-IN-76) 5mg

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