Nilvadipine

• Description :

  Nilvadipine is a potent calcium channel antagonist, and the IC50 value is around 0.1 nM.

• Product Name Alternative :

  FK235; FR34235

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/nilvadipine.html

• Purity :

  99.71

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  COC(C1=C(C#N)NC(C)=C(C(OC(C)C)=O)C1C2=CC([N+]([O-])=O)=CC=C2)=O

• Molecular Formula :

  C19H19N3O6

• Molecular Weight :

  385.37

• Precautions :

  H302

• References & Citations :

  [1]Nomoto A, et al. Smooth muscle cell migration induced by inflammatory cell products and its inhibition by a potent calcium antagonist, Nilvadipine. Atherosclerosis. 1988 Aug;72 (2-3) :213-9.|[2]Nomoto A, et al. Antiatherogenic activity of FR34235 (Nilvadipine), a new potent calcium antagonist. Effect on cuff-induced intimal thickening of rabbit carotid artery. Atherosclerosis. 1987 Apr;64 (2-3) :255-61.|[3]Sugawara H, et al. Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation. Hypertens Res. 1996 Dec;19 (4) :223-8.|[4]Yamazaki H, et al. Preservation of retinal morphology and functions in royal college surgeons rat by Nilvadipine, a Ca (2+) antagonist. Invest Ophthalmol Vis Sci. 2002 Apr;43 (4) :919-26.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [75530-68-6]