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Luzopeptin A

CAT: 0804-HY-130050Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-130050Size:1 mg
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Description
Luzopeptin A (BBM-928 A) is an actinoleukin-like antitumor antibiotic. Luzopeptin A is a bifunctional DNA intercalator which can interact with isolated DNA molecules. Luzopeptin A induces an unwinding-rewinding process of the closed superhelical PM2 DNA. Luzopeptin A is active against HIV-1 and HIV-2 reverse transcriptase with IC50s of 7 nM and 68 nM for HIV-1 RT and HIV-2 RT, respectively[1][2].
CAS Number
75580-37-9
Product Name Alternative
BBM-928 A
UNSPSC
12352005
Target
Antibiotic; HIV
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/luzopeptin-a.html
Solubility
10 mM in DMSO
Smiles
O=C1N2[C@@](C(NCC(N(CC(N([C@H](C(OC[C@H](C(N3[C@]([C@H](CC=N3)OC(C)=O)([H])C(NCC(N(CC(N([C@H](C(OC[C@H]1NC(C4=NC5=C(C=C(C=C5)OC)C=C4O)=O)=O)C(C)(O)C)C)=O)C)=O)=O)=O)NC(C6=NC7=C(C=C(C=C7)OC)C=C6O)=O)=O)C(C)(O)C)C)=O)C)=O)=O)([H])[C@H](CC=N2)OC(C)=O
Molecular Formula
C64H78N14O24
Molecular Weight
1427.38
References & Citations
[1]Konishi M, Ohkuma H, Sakai F, et al. Structures of BBM-928 A, B, and C. Novel antitumor antibiotics from Actinomadura luzonensis[J]. Journal of the American Chemical Society, 1981, 103 (5) : 1241-1243.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
HIV-1; HIV-2

Alternative Products

CatalogName
sc-202214Luzopeptin A
MBS651303-01Luzopeptin A (Antibiotic BBM-928A)

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