Anti-GITR / Tnfrsf18 (Mouse)(DTA-1), CF405S conjugate
CAT:
37-BNC040976-500
Size:
500 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-GITR / Tnfrsf18 (Mouse)(DTA-1), CF405S conjugate
- Description: GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response.
- Synonyms: Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18
- CAS Number: 9007-83-4
- UNSPSC: 41116161
- UNSPSC Description: Primary and secondary antibodies for multiple methodology immunostaining detection application
- Gene Name: TNFRSF18
- Gene ID: 21936
- NCBI Gene ID: 3180
- UniProt: O35714
- Cellular Locus: Plasma membrane
- Host: Rat
- Species Reactivity: Mouse
- Immunogen: Mouse CD25 CD4 T cells
- Target Antigen: GITR | Tnfrsf18
- Clonality: Monoclonal
- Isotype: IgG2b κ
- Clone: DTA-1
- Conjugation: CF405S
- Source: Animal
- Applications: Flow, surface (published) | Functional studies (published)
- Validated Applications: FC, Functional assays
- Field of Research: Immunology, Inflammation
- Positive Control: CD25 CD4 Tregs.
- Concentration: 0.1 mg/mL
- Buffer: PBS, 0.1% BSA, 0.05% azide
- Molecular Weight: 66-70 kDa (Homodimer)
- Additionnal Information: Flow cytometry: 0.5-1 ug/million cells in 0.1 mL|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Immunofluorescence: 0.5-1 ug/mL|Optimal dilution for a specific application should be determined by user
- References & Citations: Note: References for this clone sold by other suppliers may be listed for expected applications. Clin Cancer Res (2013) 19(5): 1044-53. (functional studies) J Immunol (2019) 203:864-872. (Flow)
- Shipping Conditions: Room temperature
- Storage Conditions: 4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.
- Shelf Life: 2 years