Rabbit anti Human S100P-Binding Protein

• Background:

  The function of this binding protein is not fully known. It is known to interact with the S100P and colocalizes with S100P in the nucleus. S100P may stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).

• Synonyms:

  S100PBP

• UniProt:

  Q96BU1

• Host:

  Rabbit

• Species Reactivity:

  Human

• Isotype:

  IgG

• Conjugation:

  Affinity Purified

• Type:

  Antigen Immunoaffinity Purified Polyclonal

• Applications:

  WB, Enzyme Immunoassay, IHC

• Field of Research:

  Signal Transduction

• Purification Method:

  Antigen Immunoaffiinity Purification

• Assay Principle:

  Optimal concentration should be evaluated by serial dilutions.

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations:

  1. Dowen, S.E., et al. ‘Expression of S100P and its novel binding partner S100PBPR in early pancreatic cancer.’ Am. J. Pathol., 166, 81-92 (2005) 2. Deng, H., et al. ‘Usefulness of S100P in diagnosis of adenocarcinoma of pancreas on fine-needle aspiration biopsy specimens.’ Am. J. Clin. Pathol., 129, 81-88 (2008)

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB

• CAS Number:

  9007-83-4