Anti-BTLA(BTLA/1528), CF740 conjugate

• Description:

  B and T lymphocyte attenuator (BTLA) is a member of the CD28 Ig superfamily of inhibitory co-receptors, along with CTLA-4 and PD-1. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family receptors. Rather, it is engaged by herpesvirus entry mediator (HVEM), a member of the TNF receptor superfamily, leading to an inhibited immune response. It also plays a role in immune tolerance. BTLA is expressed on most CD4 and CD8 T cells, B cells, macrophages, dentritic cells, and NK cell. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

• Synonyms:

  BTLA; B and T lymphocyte associated protein; B and T lymphocyte attenuator; CD272

• UNSPSC:

  41116161

• UNSPSC Description:

  Primary and secondary antibodies for multiple methodology immunostaining detection application

• Gene Name:

  BTLA

• Gene ID:

  151888

• NCBI Gene ID:

  445162

• UniProt:

  Q7Z69

• Cellular Locus:

  Plasma membrane

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Recombinant full-length human BTLA protein

• Target Antigen:

  BTLA | CD272

• Clonality:

  Monoclonal

• Isotype:

  IgG2b κ

• Clone:

  BTLA/1528

• Conjugation:

  CF740

• Source:

  Animal

• Field of Research:

  Immunology

• Positive Control:

  Human lymph node or MDAMB468 xenograft.

• Concentration:

  0.1 mg/mL

• Buffer:

  PBS, 0.1% rBSA, 0.05% azide

• Molecular Weight:

  33 kDa

• Additionnal Information:

  For coating for ELISA, order Ab without BSA|Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody|Optimal dilution and staining procedure for a specific application should be determined by user|Recommended starting concentrations for titration are 1-2 ug/mL for most applications, or 1 ug/million cells/100 uL for flow cytometry

• Shipping Conditions:

  Room temperature

• Storage Conditions:

  4°C; Protect from light; Stable at room temperature or 37°C (98°F) for 7 days.

• Shelf Life:

  2 years

• CAS Number:

  9007-83-4