AZ11657312

CAT: 0804-HY-122282Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-122282Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AZ11657312 is a P2X7 receptor antagonist with activity to restore stress natriuresis. AZ11657312 significantly increased renal medullary perfusion, only in mice treated with angiotensin II. AZ11657312 improves tissue oxygenation by blocking P2X7R, especially in areas of the kidney that are underoxygenated. Administration of AZ11657312 increased sodium excretion up to sixfold while normalizing blood pressure[1].

CAS Number

804561-22-6

UNSPSC

12352005

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/az11657312.html

Smiles

O=C(CC12CC3CC(CC(C2)C3)C1)NC4=CC(C(N5CC6OC(C5)CNC6)=O)=CC=C4C

Molecular Formula

C26H35N3O3

Molecular Weight

437.57

References & Citations

[1]Inhibition of the purinergic P2X7 receptor improves renal perfusion in angiotensin-II-infused rats

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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T26700-01	AZ11657312 Free Base

AZ11657312

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