Linalool

• UNSPSC Description:

  Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities[1][2][3][4][5].

• Target Antigen:

  Apoptosis; Bacterial; Endogenous Metabolite; iGluR; TNF Receptor

• Type:

  Natural Products

• Related Pathways:

  Anti-infection;Apoptosis;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/linalool.html

• Purity:

  99.11

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C=CC(O)(C)CC/C=C(C)/C

• Molecular Weight:

  154.253

• References & Citations:

  [1]Oner Z1, et al. The protective and therapeutic effects of linalool against doxorubicin-induced cardiotoxicity in Wistar albino rats. Hum Exp Toxicol. 2019 Apr 12:960327119842634.|[2]Jun HJ, et al. Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.|[3]Jana S, et al. Antitumorigenic potential of linalool is accompanied by modulation of oxidative stress: an in vivo study in sarcoma-180 solid tumor model. Nutr Cancer. 2014;66(5):835-48. |[4]Rodenak-Kladniew B, et al. Anti-cancer mechanisms of linalool and 1,8-cineole in non-small cell lung cancer A549 cells. Heliyon. 2020 Dec 15;6(12):e05639. |[5]An Q, et al. Recent updates on bioactive properties of linalool. Food Funct. 2021 Nov 1;12(21):10370-10389.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  78-70-6