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Recombinant Human CREB-binding protein (CREBBP), partial

CAT: 0399-CSB-EP838805HU1-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP838805HU1-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
Histone lysine acetyltransferase CREBBP; Protein-lysine acetyltransferase CREBBP
Abbreviation
Recombinant Human CREBBP protein, partial
Gene Name
CREBBP
UniProt
Q92793
Expression Region
1081-1197aa
Organism
Homo sapiens (Human)
Target Sequence
RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG
Tag
N-terminal GST-tagged
Type
In Stock Protein
Source
E.coli
Field of Research
Cancer
Relevance
Acetylates histones, giving a specific tag for transcriptional activation (PubMed:24616510) . Also acetylates non-histone proteins, like DDX21, FBL, IRF2, MAFG, NCOA3, POLR1E/PAF53 and FOXO1 (PubMed:10490106, PubMed:11154691, PubMed:12738767, PubMed:12929931, PubMed:9707565, PubMed:24207024, PubMed:28790157, PubMed:30540930) . Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221) . Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902) . Acetylates POLR1E/PAF53, leading to decreased association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024) . Acetylates DDX21, thereby inhibiting DDX21 helicase activity (PubMed:28790157) . Acetylates FBL, preventing methylation of 'Gln-105' of histone H2A (H2AQ104me) (PubMed:30540930) . Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493) .
Endotoxin
Not test
Purity
Greater than 85% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Molecular Weight
40.7 kDa
References & Citations
"SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability." Song C., Hotz-Wagenblatt A., Voit R., Grummt I. Genes Dev. 31:1370-1381 (2017)
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Partial

UniProtKB · Q92793

CREB-binding protein

CBP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92793
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CREBBP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
D3DUC9, O00147, Q16376, Q4LE28
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondMethylationPhosphoproteinUbl conjugation

Molecular function

ActivatorAcyltransferaseTransferase

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

Biological rhythmsHost-virus interactionTranscriptionTranscription regulation

Domain

BromodomainRepeatZinc-finger

Cellular component

CytoplasmNucleus

Disease

Disease variantIntellectual disability

Ligand

Metal-bindingZinc

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