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TB500

CAT: 0804-HY-P0170-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0170-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TB500 is a synthetic version of an active region of thymosin β4. TB500 exhibits anti-fibrotic and wound healing activities by inhibiting the Akt signaling pathway and binding to actin. TB500 is claimed to promote endothelial cell differentiation, angiogenesis in dermal tissues, keratinocyte migration, collagen deposition and decrease inflammation[1][2][3].
CAS Number
885340-08-9
UNSPSC
12352209
Target
Akt; Drug Derivative; P2X Receptor
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Others; PI3K/Akt/mTOR
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/TB500-2.html
Purity
99.81
Solubility
H2O : 250 mg/mL (ultrasonic)
Smiles
O=C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(C)C)NC(C)=O
Molecular Formula
C38H68N10O14
Molecular Weight
889.01
References & Citations
[1]Emmie N M Ho, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69.|[2]Esposito S, et al., Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012 Sep;4 (9) :733-8.|[3]Huang CM, et al., In vivo detection of secreted proteins from wounded skin using capillary ultrafiltration probes and mass spectrometric proteomics. Proteomics. 2006 Nov;6 (21) :5805-14.|[4]Shah R, et al., Thymosin β4 inhibits PDGF-BB induced activation, proliferation, and migration of human hepatic stellate cells via its actin-binding domain. Expert Opin Biol Ther. 2018 Jul;18 (sup1) :177-184.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
No Development Reported

Alternative Products

CatalogName
TB2TB500
JH914320TB500 fragment
GTR19153906-01TB500-2
BT20TB500 (Thymosin B4 Acetate)
FRA23TB500 Frag 17-23
TBF10TB500 (Fragment 17-24)
BT-20Blend  BPC157 10mg + TB500 10mg
TB5TB500 (Thymosin B4 AceTate) (Peptide)
BT-04Blend BPC157 2mg+TB500 2mg
BT-30Blends BPC157 15mg+TB500 15mg

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