SR 11302
CAT:
804-HY-15870-01
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: Yes
SR 11302
- CAS Number: 160162-42-5
- UNSPSC Description: SR 11302 is an activator protein-1 (AP-1) transcription factor inhibitor. SR 11302 is a retinoid that specifically inhibits AP-1 activity without activating the transcription of retinoic acid response element (RARE)[1].
- Target Antigen: AP-1
- Type: Reference compound
- Related Pathways: Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Cancer; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/sr-11302.html
- Solubility: DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C)
- Smiles: O=C(O)/C=C(C)/C=C/C=C(C1=CC=C(C)C=C1)/C=C/C2=C(C)CCCC2(C)C
- Molecular Weight: 376.53
- References & Citations: [1]C Huang, et al. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid. Proc Natl Acad Sci U S A. 1997 May 27;94(11):5826-30.|[2]Bradley A Maron, et al. Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation. 2014 Jul 8;130(2):168-79.|[3]Eunyoung Byun, et al. Activation of NF-κB and AP-1 Mediates Hyperproliferation by Inducing β-Catenin and c-Myc in Helicobacter pylori-Infected Gastric Epithelial Cells. Yonsei Med J. 2016 May;57(3):647-51.|[4]Ye Sun, et al. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 Jun 5;214(6):1753-1767.
- Shipping Conditions: Dry Ice
- Clinical Information: No Development Reported