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PU02

CAT: 0804-HY-103118-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103118-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PU02, a derivative of 6-MP , is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively[1][2].
CAS Number
313984-77-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor; Apoptosis
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pu02.html
Purity
99.76
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C12=NC=NC(SCC3=C4C=CC=CC4=CC=C3)=C1N=CN2
Molecular Formula
C16H12N4S
Molecular Weight
292.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Sarah M Trattnig, et al. Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site. J Biol Chem. 2012 Jul 20;287 (30) :25241-54.|[2]Xiao-Guang Yang, et al. 6-[ (1-naphthylmethyl) sulfanyl]-9H-purine induces G2/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Eur J Pharmacol. 2012 Nov 15;695 (1-3) :27-33.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT3 Receptor; lactoferrin

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