Trigonelline

CAT: 0804-HY-N0414-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N0414-01Size:5 mg
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Description
Trigonelline is an alkaloid with potential antidiabetic activity that can be isolated from Trigonella foenum-graecum L or Leonurus artemisia. Trigonelline is a potent Nrf2 inhibitor that blocks Nrf2-dependent proteasome activity, thereby enhancing apoptosis in pancreatic cancer cells. Trigonelline also has anti-HSV-1, antibacterial, and antifungal activity and induces ferroptosis.
CAS Number
[535-83-1]
Product Name Alternative
Trigenolline
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Endogenous Metabolite; Ferroptosis; Fungal; HIV
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Trigonelline.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 7.14 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
C[N+]1=CC(C([O-])=O)=CC=C1
Molecular Formula
C7H7NO2
Molecular Weight
137.14
Precautions
H302, H315, H319, H335
References & Citations
[1]Ilavenil S, et al. Trigonelline protects the cardiocyte from hydrogen peroxide induced apoptosis in H9c2 cells. Asian Pac J Trop Med. 2015 Apr;8 (4) :263-8.|[2]Joanna Folwarczna, et al. Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System. Nutrients. 2016 Mar; 8 (3) : 133.|[3]A Arlt, et al. Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity. Oncogene. 2013 Oct;32 (40) :4825-35.|[4]Ozçelik B, et al. Cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids. Pharm Biol. 2011 Apr;49 (4) :396-402.|[5]Su Y, et al. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020 Jul 28;483:127-136.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Citation 01
Adv Sci (Weinh) . 2024 Mar;11 (10) :e2305563.|Int J Mol Sci. 2023 Feb 7;24 (4) :3257.|J Agric Food Chem. 2022 Jun 22;70 (24) :7420-7440.|J Ginseng Res. 2023 Jan;47 (1) :106-116.|SSRN. 2025 Jul 9.|Adv Sci (Weinh) . 2025 Nov 5:e13956.

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