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Dp44mT

CAT: 0804-HY-18973-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18973-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dp44mT is an iron chelator with selective anticancer activity.
CAS Number
152095-12-0
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Dp44mT.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
S=C(N/N=C(C1=NC=CC=C1)\C2=NC=CC=C2)N(C)C
Molecular Formula
C14H15N5S
Molecular Weight
285.37
Precautions
H301
References & Citations
[1]Rao VA, et al. The iron chelator Dp44mT causes DNA damage and selective inhibition of topoisomerase IIalpha in breast cancer cells. Cancer Res. 2009 Feb 1;69 (3) :948-57.|[2]Lovejoy DB, et al. Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes. Cancer Res. 2011 Sep 1;71 (17) :5871-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported