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Butacaine

CAT: 0804-HY-B1007-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1007-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Butacaine is a reversible nerve conduction blocker. Butacaine acts on the nervous system and nerve fibers, can cause both sensory and motor paralysis. Butacaine inhibits the NavBh currents. Butacaine can form inclusion complexes with α-cyclodextrin (α-CD) and β-cyclodextrin (β-CD) . Butacaine is commonly used as a negative control for other local anesthetics[1][2][3].
CAS Number
149-16-6
UNSPSC
12352005
Hazard Statement
H301
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Butacaine.html
Purity
99.84
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CCCCN(CCCOC(C1=CC=C(N)C=C1)=O)CCCC
Molecular Formula
C18H30N2O2
Molecular Weight
306.44
Precautions
H301
References & Citations
[1]Hashemianzadeh S M, et al. Quantum chemical study of the host-guest inclusion complexes of the local anaesthetic drugs, procaine hydrochloride and butacaine hydrochloride, with α-and β-cyclodextrins[J]. Monatshefte für Chemie-Chemical Monthly, 2008, 139 (7) : 763-771. |[2]Miller ZA, et al. Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14. Cell Rep. 2023 Dec 26;42 (12) :113437. |[3]Fan X, et al. Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation. Stem Cell Res Ther. 2021 Feb 4;12 (1) :107.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Launched

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