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Tasiamide B

CAT: 0804-HY-N15154Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N15154Size:1 Each
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Description
Tasiamide B is a Cathepsin D inhibitor, which is a linear peptide found in the marine cyanobacteria Symploca sp.. Tasiamide B is proved as a good template for the development of aspartic proteases inhibitors. Tasiamide B is effective against skin cancer by strongly interacting with the target protein HSP90[1][2].
CAS Number
587014-85-5
UNSPSC
12352005
Target
Cathepsin; HSP
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tasiamide-b.html
Smiles
C[C@H](O)C(N[C@@H](C(C)C)C(N(C)[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)[C@@H](O)CC(N[C@@H](CC(C)C)C(N[C@@H](C)C(N(C)[C@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(OC)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C50H74N8O12
Molecular Weight
979.17
References & Citations
[1]Li Z, et al. Design, synthesis, and bioactivities of tasiamide B derivatives as cathepsin D inhibitors. J Pept Sci. 2019 Apr;25 (4) :e3154.|[2]Vijayakumar S, et al. Tasiamide-B a new cyanobacterial compound for treating skin cancer[J]. Biomedicine & Preventive Nutrition, 2014, 4 (3) : 355-358.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Cathepsin D; HSP90

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