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Fraxinellone

CAT: 0804-HY-N0242-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0242-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fraxinellone is isolated from the root bark of the Rutaceae plant, Dictamnus dasycarpus. Fraxinellone is a PD-L1 inhibitor and inhibits HIF-1α protein synthesis without affecting HIF-1α protein degradation. Fraxinellone has the potential to be a valuable candidate for cancer treatment by targeting PD-L1[1].
CAS Number
28808-62-0
UNSPSC
12352005
Hazard Statement
H301, H361
Target
HIF/HIF Prolyl-Hydroxylase; PD-1/PD-L1; STAT
Type
Natural Products
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fraxinellone.html
Concentration
10mM
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1O[C@@H](C2=COC=C2)[C@]3(C)CCCC(C)=C31
Molecular Formula
C14H16O3
Molecular Weight
232.28
Precautions
H301, H361
References & Citations
[1]Xing Y, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018 Sep;135:166-180.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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