ADAMTS-5-IN-3

ADAMTS-5-IN-3

• CAS Number: 2688733-96-0
• UNSPSC Description: ADAMTS-5-IN-3 (Example 37-2) is a potent inhibitor of ADAMTS-5 and ADAMTS-4 with IC50s of 8 and 12 nM, respectively. ADAMTS-5-IN-3 can be used for the research of diseases involving degradation of cartilage or disruption of cartilage homeostasis, in particular osteoarthrosis and/or rheumatoid arthritis[1].
• Target Antigen: ADAMTS
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/adamts-5-in-3.html
• Solubility: DMSO : 200 mg/mL (ultrasonic)
• Smiles: O=C(N1C[C@@H](C2=CC(Cl)=C(Cl)C=C2CC1)C)CC[C@]3(C4CC4)C(NC(N3)=O)=O
• Molecular Weight: 424.32
• References & Citations: [1]Dong Liu, et al. Adamts inhibitors, preparation methods and medicinal uses thereof. WO2021158626A1.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported