Cimaterol

• UNSPSC Description:

  Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice[1]. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM)[2].

• Target Antigen:

  Adrenergic Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/cimaterol.html

• Purity:

  99.13

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  N#CC1=CC(C(O)CNC(C)C)=CC=C1N

• Molecular Weight:

  219.28

• References & Citations:

  [1]H C Walker, et al. Effects of cimaterol, a beta-adrenergic agonist, on energy metabolism in ob/ob mice. Am J Physiol. 1988 Dec;255(6 Pt 2):R952-60.|[2]J M Harper, et al. The effects of beta agonists on muscle cells in culture. Domest Anim Endocrinol. 1990 Oct;7(4):477-84.|[3]Boimpoundi Eunice Flavie Ouali, et al. Beta-agonist drugs modulate the proliferation and differentiation of skeletal muscle cells in vitro. Biochem Biophys Rep. 2021 May 18;26:101019.|[4]W R Walker, et al. Evaluation of cimaterol for finishing swine including a drug withdrawal period. J Anim Sci. 1989 Jan;67(1):168-76.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  54239-37-1