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Cimaterol

CAT: 0804-HY-100935-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100935-01Size:5 mg
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Description
Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice[1]. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM) [2].
CAS Number
54239-37-1
Product Name Alternative
CL 263780; (±) -2-Amino-5-[1-hydroxy-2-[ (1-methylethyl) amino]ethyl]benzonitrile
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/cimaterol.html
Purity
99.13
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N#CC1=CC(C(O)CNC(C)C)=CC=C1N
Molecular Formula
C12H17N3O
Molecular Weight
219.28
Precautions
H302, H315, H319, H335
References & Citations
[1]H C Walker, et al. Effects of cimaterol, a beta-adrenergic agonist, on energy metabolism in ob/ob mice. Am J Physiol. 1988 Dec;255 (6 Pt 2) :R952-60.|[2]J M Harper, et al. The effects of beta agonists on muscle cells in culture. Domest Anim Endocrinol. 1990 Oct;7 (4) :477-84.|[3]Boimpoundi Eunice Flavie Ouali, et al. Beta-agonist drugs modulate the proliferation and differentiation of skeletal muscle cells in vitro. Biochem Biophys Rep. 2021 May 18;26:101019.|[4]W R Walker, et al. Evaluation of cimaterol for finishing swine including a drug withdrawal period. J Anim Sci. 1989 Jan;67 (1) :168-76.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor

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