Cimaterol

• Description :

  Cimaterol (CL 263780) is a β-adrenergic agonist on energy metabolism in ob/ob mice[1]. The Kd for Cimaterol binding to the L6 β-receptor is 26 nM which is compatible with its EC50 for the stimulation of protein synthesis (approx 5 nM) [2].

• Product Name Alternative :

  CL 263780; (±) -2-Amino-5-[1-hydroxy-2-[ (1-methylethyl) amino]ethyl]benzonitrile

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Adrenergic Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/cimaterol.html

• Purity :

  99.13

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  N#CC1=CC(C(O)CNC(C)C)=CC=C1N

• Molecular Formula :

  C12H17N3O

• Molecular Weight :

  219.28

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]H C Walker, et al. Effects of cimaterol, a beta-adrenergic agonist, on energy metabolism in ob/ob mice. Am J Physiol. 1988 Dec;255 (6 Pt 2) :R952-60.|[2]J M Harper, et al. The effects of beta agonists on muscle cells in culture. Domest Anim Endocrinol. 1990 Oct;7 (4) :477-84.|[3]Boimpoundi Eunice Flavie Ouali, et al. Beta-agonist drugs modulate the proliferation and differentiation of skeletal muscle cells in vitro. Biochem Biophys Rep. 2021 May 18;26:101019.|[4]W R Walker, et al. Evaluation of cimaterol for finishing swine including a drug withdrawal period. J Anim Sci. 1989 Jan;67 (1) :168-76.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  β adrenergic receptor

• CAS Number :

  [54239-37-1]