7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol

7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol

• CAS Number: 6272-55-5
• UNSPSC Description: 7,8,9,10-Tetrahydrobenzo[a]pyren-7-ol is a benzopyrene derivative that is activated by hepatic cytosol into electrophilic sulfuric acid esters[1], which are capable of forming covalent DNA adducts and inducing mutations[2].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/7-8-9-10-tetrahydrobenzo-pqr-tetraphen-7-ol.html
• Purity: 98.09
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: OC1CCCC2=C3C=CC4=CC=CC5=C4C3=C(C=C21)C=C5
• Molecular Weight: 272.347
• References & Citations: [1]Glatt H, Pauly K, Frank H, Seidel A, Oesch F, Harvey RG, Werle-Schneider G. Substance-dependent sex differences in the activation of benzylic alcohols to mutagens by hepatic sulfotransferases of the rat. Carcinogenesis. 1994 Nov;15(11):2605-11.|[2]Surh YJ, Tannenbaum SR. Sulfotransferase-mediated activation of 7,8,9,10-tetrahydro-7-ol, 7,8-dihydrodiol, and 7,8,9,10-tetraol derivatives of benzo[a]pyrene. Chem Res Toxicol. 1995 Jul-Aug;8(5):693-8.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported