TOFA

• Description:

  TOFA (RMI14514; MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA) .

• Product Name Alternative:

  RMI14514; MDL14514

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Acetyl-CoA Carboxylase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/TOFA.html

• Purity:

  99.91

• Solubility:

  DMSO : 11.36 mg/mL (ultrasonic)

• Smiles:

  O=C(C1=CC=C(OCCCCCCCCCCCCCC)O1)O

• Molecular Formula:

  C19H32O4

• Molecular Weight:

  324.45

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Wang C, et al. Acetyl-CoA carboxylase-alpha inhibitor TOFA induces human cancer cell apoptosis. Biochem Biophys Res Commun. 2009 Jul 31;385 (3) :302-6.|[2]Li S, et al. TOFA suppresses ovarian cancer cell growth in vitro and in vivo. Mol Med Rep. 2013 Aug;8 (2) :373-8.|[3]Guseva NV, et al. TOFA (5-tetradecyl-oxy-2-furoic acid) reduces fatty acid synthesis, inhibits expression of AR, neuropilin-1 and Mcl-1 and kills prostate cancer cells independent of p53 status. Cancer Biol Ther. 2011 Jul 1;12 (1) :80-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [54857-86-2]