Products for Research Use Only
RegisterLogin

Isomangiferin

CAT: 0804-HY-N0772-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N0772-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin. Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing[1][2][3][4][5].
CAS Number
24699-16-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Acetyl-CoA Carboxylase; AMPK; Apoptosis; Bacterial; HSV; NF-κB; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS) ; VEGFR
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Isomangiferin.html
Concentration
10mM
Purity
99.60
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC1=CC(O)=C2C(OC3=CC(O)=C(O)C=C3C2=O)=C1[C@@H]([C@@H]([C@@H](O)[C@@H]4O)O)O[C@@H]4CO
Molecular Formula
C19H18O11
Molecular Weight
422.34
Precautions
H302, H315, H319, H335
References & Citations
[1]Zheng MS, et al. Antiviral effect of mangiferin and isomangiferin on herpes simplex virus. Chin Med J (Engl) . 1990 Feb;103 (2) :160-5.|[2]Gao B, et al. Isomangiferin promotes the migration and osteogenic differentiation of rat bone marrow mesenchymal stem cells. Open Life Sci. 2024 Jul 20;19 (1) :20220884. doi: 10.1515/biol-2022-0884. PMID: 39035458; PMCID: PMC11259999.|[3]Yue S, et al. Isomangiferin Attenuates Renal Injury in Diabetic Mice via Inhibiting Inflammation. Diabetes Metab Syndr Obes. 2020 Nov 10;13:4273-4280. |[4]Wang B, et al. Isomangiferin, a Novel Potent Vascular Endothelial Growth Factor Receptor 2 Kinase Inhibitor, Suppresses Breast Cancer Growth, Metastasis and Angiogenesis. J Breast Cancer. 2018 Mar;21 (1) :11-20. |[5]Ishaque M, et al. Xanthone C-glycosides isomers purified from Dryopteris ramosa (Hope) C. Chr. with bactericidal and cytotoxic prospects. Saudi J Biol Sci. 2022 Feb;29 (2) :1191-1196.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
N2162-20Isomangiferin
371594Isomangiferin discontinued
A14801-10Isomangiferin 10mg
A14801-25Isomangiferin 25mg
A14801-5Isomangiferin 5mg
A14801-1Isomangiferin 1mg
A14801-50Isomangiferin 50mg
A14801-10mM-DIsomangiferin 10mM * 1mL in DMSO

Popular Products