XMU-MP-9

XMU-MP-9

• CAS Number: 2251130-41-1
• UNSPSC Description: XMU-MP-9 is a bifunctional compound that binds to the C2 domain of Nedd4-1 and the allosteric site of K-Ras. XMU-MP-9 enhances the interaction between Nedd4-1 and K-Ras, induces conformational changes in the Nedd4-1/K-Ras complex, promotes the ubiquitination and degradation of multiple K-Ras mutants, and inhibits the proliferation of cells carrying K-Ras mutants. XMU-MP-9 can be used in cancer research[1].
• Target Antigen: Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/xmu-mp-9.html
• Solubility: DMSO : 116.67 mg/mL (ultrasonic)
• Smiles: FC1=C(CNC(C2=CSC(C3=NNC4=CC=CC=C34)=C2)=O)C(Cl)=CC=C1
• Molecular Weight: 385.84
• References & Citations: [1]Taoling Zeng, et al. "Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1." bioRxiv (2024): 2024-04.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported