Clervonafusp alfa
CAT:
804-HY-P99803
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Clervonafusp alfa
- CAS Number: 2145123-44-8
- UNSPSC Description: Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs). Clervonafusp alfa can be used for late-onset Pompe disease research[1].
- Target Antigen: Glycosidase
- Type: Inhibitory Antibodies
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/clervonafusp-alfa.html
- Solubility: H2O
- Smiles: [Clervonafusp alfa]
- References & Citations: [1]Kishnani P, et al. Safety and efficacy of VAL-1221, a novel fusion protein targeting cytoplasmic glycogen, in patients with late-onset Pompe disease. Molecular Genetics & Metabolism, 2019, 126(2):S85-S86.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 2