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Targefrin

CAT: 0804-HY-P3717-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P3717-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC50 value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines[1].
CAS Number
3031514-44-7
UNSPSC
12352209
Target
Ephrin Receptor
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/targefrin.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H](NC([C@@H](NC([C@@H](NC(CN1CCNCC1)=O)CC2=CC=C(N)C=C2)=O)CC(C)C)=O)C(N[C@H](C(N3CCC[C@H]3C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](C4CCCCC4)C(N(CCC5)[C@@H]5C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CCCNC(N)=N)C(N7CCC[C@H]7C(N)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CC8=CC=C(C=C8)C9=CC=CC=C9C(F)(F)F)=O
Molecular Formula
C85H116F3N19O15
Molecular Weight
1700.94
References & Citations
[1]Baggio C, Udompholkul P, Gambini L, Pellecchia M. Targefrin: A Potent Agent Targeting the Ligand Binding Domain of EphA2. J Med Chem. 2022 Nov 4.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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