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Selvigaltin

CAT: 0804-HY-147041-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147041-01Size:1 mg
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Description
Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC50 value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen) . Selvigaltin restores T-cell activity and induces less tumors and metastasis[1][2][3][4].
CAS Number
1978336-95-6
Product Name Alternative
GB1211
UNSPSC
12352005
Target
Galectin
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/selvigaltin.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@@H]([C@H](O1)SC2=CN=CC(Br)=C2)[C@](N3C=C(C(C=C4F)=CC(F)=C4F)N=N3)([H])[C@H]([C@H]1CO)O
Molecular Formula
C19H16BrF3N4O4S
Molecular Weight
533.32
References & Citations
[1]Slack RJ, et al. The therapeutic potential of galectin-3 inhibition in fibrotic disease. Int J Biochem Cell Biol. 2021 Jan;130:105881. |[2]Zetterberg Fredrik, et al. Preparation of galactosides as galectins inhibitors. WO2020078808+A1. 2020 April 23.|[3]Comeglio P, et al. The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis. Front Pharmacol. 2024 Jul 31;15:1430109.|[4]Aslanis V, et al. Single‑Dose Pharmacokinetics and Safety of the Oral Galectin‑3 Inhibitor, Selvigaltin (GB1211), in Participants with Hepatic Impairment. Clin Drug Investig. 2024 Oct 2.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Galectin-3

Alternative Products

CatalogName
GTR19184871-01Selvigaltin
GTR19262656-01(2S) -Selvigaltin

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