9,10-trans-Dehydroepothilone D

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804-HY-106265

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CAS Number: 350493-61-7
UNSPSC Description: 9,10-trans-Dehydroepothilone D shows an antiproliferative activity against a paclitaxel-resistant cell lines overexpressing P-glycoprotein. 9,10-trans-Dehydroepothilone D also shows tubulin polymerization activity. 9,10-trans-Dehydroepothilone D is given by lactonization of Seco acid, which is promising for research of cancers[1].
Target Antigen: P-glycoprotein
Type: Reference compound
Related Pathways: Membrane Transporter/Ion Channel
Field of Research: Cancer
Assay Protocol: https://www.medchemexpress.com/9-10-trans-dehydroepothilone-d.html
Smiles: O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C/C=C(C)\C/C=C/[C@H](C)[C@H](O)[C@@H](C)C1=O
Molecular Weight: 489.67
References & Citations: [1]White JD, et al. Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D. J Am Chem Soc. 2001 Jun 13;123(23):5407-13.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

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