Rabbit anti Human Caveolin 1

• Background:

  Caveolin 1 is a tyrosine phosphoprotein that plays an essential role in the formation of caveolae where it acts as a scaffolding protein. It has also been shown to bind cholesterol and to be involved in the lipid transport, membrane trafficking and signal transduction. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.

• UniProt:

  Q03135

• Host:

  Rabbit

• Species Reactivity:

  Human

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Ammonium Sulfate Precipitation

• Assay Principle:

  Antibody can be used for Western blotting (1-5 µg/mL). Optimal concentration should be evaluated by serial dilutions.

• Stability:

  See expiration date on vial

• Concentration:

  See vial for Concentration

• Form:

  Provided as solution in phosphate buffered saline with 0,08% sodium azide

• Precautions:

  This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving Humans or animals.

• References & Citations:

  1. Cai, T., et al. 'Regulation of caveolin-1 membrane trafficking by the Na/K-ATPase.' J. Cell Biol. 2008, 182, 1153-1169. 2. Dittman, K., et al. 'Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK.' Mol. Cancer 2008, 7, 69. 3. Zhong, Y., et al. 'Caveolin-1 regulates Human immunodeficiency virus-1 Tat-induced alterations of tight junction protein expression via modulation of the Ras signaling.' J. Neurosci. 2008, 28, 7788-7796. 4. Tourkina, E., et al. 'Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo.' Am. J. Physiol. Lung Cell. Mol. Physiol. 2008, 294, L843-L861 5. Huang, J.H., et al. 'Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1.' J. Biol. Chem. 2007, 282, 6143-6152.

• Shipping Conditions:

  Ambient Temperature, freeze upon arrival

• Storage Conditions:

  Product should be stored at -20ºC; Aliquot to avoid freeze/thaw cycles

• Functional Analysis:

  WB

• CAS Number:

  9007-83-4