HSP27 inhibitor J2
CAT:
804-HY-124653-01
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
HSP27 inhibitor J2
- Alternative Name: J2
- CAS Number: 2133499-85-9
- UNSPSC Description: HSP27 inhibitor J2 (J2) is a HSP27 inhibitor, which significantly induces abnormal HSP27 dimer formation and inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of the HSP27 and reducing a cell protection function thereof. HSP27 inhibitor J2 (J2) remarkably enhances the antiproliferative activity of 17-AAG and sensitizes cisplatin-induced lung cancer cell growth inhibition[1][2].
- Target Antigen: HSP
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/hsp27-inhibitor-j2.html
- Purity: 99.70
- Solubility: DMSO : 20 mg/mL (ultrasonic)
- Smiles: O=C1C=C(C)OC2=C1C(O)=CC(OCC3SC3)=C2
- Molecular Weight: 264.30
- References & Citations: [1]Hwang SY, et al. Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shockprotein 27. Eur J Med Chem. 2017 Oct 20;139:892-900.|[2]Younghwa Na, et al. Methods for treating pulmonary fibrosis using chromenone derivatives.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported