Restrictocin

• Description :

  Restrictocin is a small endoribonuclease. Restrictocin cleaves one site in the conserved sarcin/ricin loop (SRL) in 23S-28S rRNA to disrupt GTPase activation when elongation factors bind to the ribosome, halt protein synthesis, and ultimately trigger apoptotic cell death[1].

• UNSPSC :

  12352204

• Hazard Statement :

  H302+H312+H332-H317-H334

• Target :

  Apoptosis; Endonuclease

• Type :

  Enzyme

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/restrictocin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [Restrictocin]

• Precautions :

  P261-P264-P270-P271-P272-P280-P284-P302+P352-P304+P340-P330-P362+P364-P501

• References & Citations :

  [1]Plantinga MJ, et al. The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues. Biochemistry. 2011 Apr 12;50 (14) :3004-13.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Enzyme

• Clinical Information :

  No Development Reported

• CAS Number :

  [1406-72-0]