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Bexmarilimab

CAT: 0804-HY-P99236-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P99236-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bexmarilimab (FP-1305) is a potent humanized anti-CLEVER-1 IgG4 antibody with an IC50 value of 4.51 nM. Bexmarilimab is capable of inducing a phenotypic M2 to M1 immune switch of tumor-associated macrophages. Bexmarilimab can promote antigen presentation and pro-inflammatory cytokine secretion. Bexmarilimab can induce B-cell and T-cell activation. Bexmarilimab can be used in researches of immunology and cancer, such as colorectal carcinoma[1][2].
CAS Number
2259301-27-2
Product Name Alternative
FP-1305
UNSPSC
12352203
Target
Transmembrane Glycoprotein
Type
Inhibitory Antibodies
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bexmarilimab.html
Purity
95.00
Solubility
10 mM in DMSO
Smiles
[Bexmarilimab]
Molecular Weight
(146.22 kDa)
References & Citations
[1]Hollmén M, et al. Nonclinical Characterization of Bexmarilimab, a Clever-1-Targeting Antibody for Supporting Immune Defense Against Cancers. Mol Cancer Ther. 2022 Jul 5;21 (7) :1207-1218.|[2]Elisa M. Vuorinen, et al. Bexmarilimab induces B-cell activation and autoantibody production. Cancer Res 1 April 2023; 83 (7_Supplement) : 2269.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2

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