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TBHQ

CAT: 0804-HY-100489-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100489-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX) -induced cardiotoxicity through activation of Nrf2[1]. TBHQ (tert-Butylhydroquinone) is also an ERK activator; rescues Dehydrocorydaline (DHC) -induced cell proliferation inhibitionin melanoma[2].
CAS Number
1948-33-0
Product Name Alternative
Tert-Butylhydroquinone
UNSPSC
12352005
Hazard Statement
H302+H312, H315, H317, H319, H410
Target
Apoptosis; Autophagy; ERK; Ferroptosis; Keap1-Nrf2
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TBHQ.html
Purity
99.93
Solubility
DMSO : ≥ 56.66 mg/mL
Smiles
OC1=CC=C(O)C=C1C(C)(C)C
Molecular Formula
C10H14O2
Molecular Weight
166.22
Precautions
H302+H312, H315, H317, H319, H410
References & Citations
[1]Lin-Feng Wang, et al. Tert-butylhydroquinone ameliorates doxorubicin-induced cardiotoxicity by activating Nrf2 and inducing the expression of its target genes. Am J Transl Res. 2015; 7 (10) : 1724–1735.|[2]Hu H, et al. Dehydrocorydaline inhibits cell proliferation, migration and invasion via suppressing MEK1/2-ERK1/2 cascade in melanoma.Onco Targets Ther. 2019 Jul 2;12:5163-5175.|[3]XIAOJING SHI, et al. Tert-butylhydroquinone attenuates the ethanol-induced apoptosis of and activates the Nrf2 antioxidant defense pathway in H9c2 cardiomyocytes.Int J Mol Med. 2016 Jul; 38 (1) : 123–130.|[4]Sukumari-Ramesh S, et al. Post-Injury Administration of Tert-butylhydroquinone Attenuates Acute Neurological Injury AfterIntracerebral Hemorrhage in Mice.J Mol Neurosci. 2016 Apr;58 (4) :525-31.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK

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