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Ornipressin

CAT: 0804-HY-P0083-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0083-01Size:5 mg
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Description
Ornipressin (POR-8) is a vasopressin agonist specific for the V1 receptor. Ornipressin can be used as a local vasoconstrictor. Ornipressin can reverse the hypotension associated with combine general/epidural anesthesia. Ornipressin has antidiuretic activity. Ornipressin decreases renal vascular resistance and increases renal blood flow in renal failure model[1][2][3][4].
CAS Number
3397-23-7
Product Name Alternative
POR-8
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Vasopressin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Ornipressin.html
Purity
99.90
Solubility
DMSO : 22.22 mg/mL (ultrasonic; adjust pH to 3 with 1 M HCl)
Smiles
O=C([C@H](CSSC[C@@H](C(N[C@H](C1=O)CC2=CC=C(O)C=C2)=O)N)NC([C@@H](NC([C@@H](NC([C@](N1)([H])CC3=CC=CC=C3)=O)CCC(N)=O)=O)CC(N)=O)=O)N(CCC4)[C@@H]4C(N[C@@H](CCCN)C(NCC(N)=O)=O)=O
Molecular Formula
C45H63N13O12S2
Molecular Weight
1042.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Fruhstorfer H, et al. Dose-response relation of ornipressin with regard to vasoconstriction in human skin. Br J Anaesth. 1994 Aug;73 (2) :220-4.|[2]De Kock M, et al. Ornipressin (Por 8) : An efficient alternative to counteract hypotension during combined general/epidural anesthesia. Anesth Analg. 2000 Jun;90 (6) :1301-7.|[3]Kam, P. C., & Tay, T. M. (1998) . The pharmacology of ornipressin (POR-8) : a local vasoconstrictor used in surgery. European journal of anaesthesiology, 15 (2), 133–139.|[4]Lenz, K., et al., (1991) . Ornipressin in the treatment of functional renal failure in decompensated liver cirrhosis. Effects on renal hemodynamics and atrial natriuretic factor. Gastroenterology, 101 (4), 1060–1067.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Launched

Chemical Information

Ornipressin

Ornipressin is an oligopeptide.

CAS Number3397-23-7
PubChem CID14257660
IUPAC Name(2S)-N-[(2S)-5-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Molecular FormulaC45H63N13O12S2
Molecular Weight1042.2
XLogP-4.2
Topological Polar Surface Area476
Hydrogen Bond Donor Count13
Hydrogen Bond Acceptor Count16
Rotatable Bond Count18
Heavy Atom Count72
Formal Charge0
Complexity1940
SMILES
C1C[C@H](N(C1)C(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)N)C(=O)N[C@@H](CCCN)C(=O)NCC(=O)N
InChI
InChI=1S/C45H63N13O12S2/c46-16-4-8-28(39(64)51-21-37(50)62)53-44(69)34-9-5-17-58(34)45(70)33-23-72-71-22-27(47)38(63)54-30(19-25-10-12-26(59)13-11-25)42(67)55-31(18-24-6-2-1-3-7-24)41(66)52-29(14-15-35(48)60)40(65)56-32(20-36(49)61)43(68)57-33/h1-3,6-7,10-13,27-34,59H,4-5,8-9,14-23,46-47H2,(H2,48,60)(H2,49,61)(H2,50,62)(H,51,64)(H,52,66)(H,53,69)(H,54,63)(H,55,67)(H,56,65)(H,57,68)/t27-,28-,29-,30-,31-,32-,33-,34-/m0/s1
InChIKey
MUNMIGOEDGHVLE-LGYYRGKSSA-N
Chemical Structure
2D Structure
2D structure of Ornipressin
CAS: 3397-23-7
CID: 14257660
Formula: C45H63N13O12S2
MW: 1042.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1042.2
XLogP3-4.2
Hydrogen Bond Donor Count13
Hydrogen Bond Acceptor Count16
Rotatable Bond Count18
Exact Mass1041.41605684
Monoisotopic Mass1041.41605684
Topological Polar Surface Area476 Ų
Heavy Atom Count72
Formal Charge0
Complexity1940
Isotope Atom Count0
Defined Atom Stereocenter Count8
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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