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Ogremorphin

CAT: 0804-HY-154954-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-154954-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ogremorphin (OGM) is a G protein coupled sensor GPR68 inhibitor with anti-inflammatory and anti-tumor activities. Ogremorphin can inhibit the migration of human melanoma cells and induce ferroptosis in glioblastoma cells[1][2][3].
CAS Number
352563-21-4
Product Name Alternative
OGM; GPR68-IN-1; OGM-8345
UNSPSC
12352005
Target
Ferroptosis; GPR68
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ogremorphin.html
Purity
99.60
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=C(CC)C=C2C13SC(C4=C5C=CC=CC5=CC=C4)=NN3
Molecular Formula
C21H17N3OS
Molecular Weight
359.44
References & Citations
[1]Karki P, et al. A Novel Group of Ogremorphin Inhibitors Targeting G Protein-coupled Sensor GPR68 Rescue Lipopolysaccharide or Acidosis-induced Lung Endothelial Dysfunction[M]//C108. MECHANISMS OF LUNG INFLAMMATION AND INFECTION. American Thoracic Society, 2024: A6846-A6846.|[2]Williams C H, et al. Coupling Metastasis to pH-Sensing GPR68 Using a Novel Small Molecule Inhibitor[J]. BioRxiv, 2019: 612549.|[3]Williams C H, et al. GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment. Exp Hematol Oncol. 2024 Jan 31;13 (1) :13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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