Prostaglandin E2-1-glyceryl ester-d5

• UNSPSC Description:

  Prostaglandin E2-1-glyceryl ester-d5 (PGE2-1-glyceyl ester-d5) is deuterium labeled Prostaglandin E2-1-glyceryl ester. Prostaglandin E2-1-glyceryl ester, a Prostaglandin Glycerol Ester, is an endocannabinoid ligand for the CB1 receptor. Prostaglandin E2-1-glyceryl ester induces rapid, transient elevation of intracellular free Ca2+[1][2].

• Target Antigen:

  Cannabinoid Receptor; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling;Others

• Field of Research:

  Cancer;Metabolic Disease

• Smiles:

  O=C1[C@@H]([C@H]([C@@H](C1)O)/C=C/[C@H](CCCCC)O)C/C=C\CCCC(OC([2H])(C([2H])(C([2H])(O)[2H])O)[2H])=O

• Molecular Weight:

  431.57

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]K R Kozak, et al. Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo. J Biol Chem. 2001 Oct 5;276(40):36993-8.|[3]T Sugiura, et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. Biochem Biophys Res Commun. 1996 Dec 4;229(1):58-64.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2