1,8-Dihydroxy-4,5-dinitroanthraquinone

1,8-Dihydroxy-4,5-dinitroanthraquinone

• Product Name Alternative: ARDP0006; DHDNE
• CAS Number: 81-55-0
• UNSPSC Description: 1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].
• Target Antigen: Dengue virus; Flavivirus; Virus Protease
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/1-8-dihydroxy-4-5-dinitroanthraquinone.html
• Purity: 98.00
• Solubility: DMSO : 41.67 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=C1C2=C(C(C3=C(C=CC(O)=C13)[N+]([O-])=O)=O)C([N+]([O-])=O)=CC=C2O
• Molecular Weight: 330.208
• References & Citations: [1]Constant DA, et al. Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10136-10141.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported