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Chlorasquin

CAT: 0804-HY-121256Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121256Size:1 Each
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Description
Chlorasquin inhibits thymidylate synthetase with an approximate Ki value of 4.9 μM. Chlorasquin is also a folate antagonist, testing the Methotrexate effect. Chlorasquin binds tighter to dihydrofolate reductase at alkaline pH than does Methotrexate, which is promising for research of antipsoriatic agents[1][2].
CAS Number
18921-73-8
UNSPSC
12352005
Target
Antifolate; Dihydrofolate reductase (DHFR) ; Thymidylate Synthase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/chlorasquin.html
Smiles
O=C(C[C@H](NC(C1=CC=C(C=C1)NCC2=C(C3=C(N=C(N=C3C=C2)N)N)Cl)=O)C(O)=O)O
Molecular Formula
C20H19ClN6O5
Molecular Weight
458.86
References & Citations
[1]Chello PL, et al. Elevation of dihydrofolate reductase, thymidylate synthetase, and thymidine kinase in cultured mammalian cells after exposure to folate antagonists. Cancer Res. 1976 Jul;36 (7 PT 1) :2442-9. |[2]Hynes J B, et al. Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogs of folic and isofolic acids[J]. Journal of Medicinal Chemistry, 1977, 20 (4) : 588-591.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
MBS5773647Chlorasquin

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