Pyr3

• Description:

  Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC50 of 700 nM for TRPC3-mediated Ca2+ influx.

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H314

• Target:

  TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/Pyr3.html

• Concentration:

  10mM

• Purity:

  99.90

• Solubility:

  DMSO : ≥ 125 mg/mL

• Smiles:

  O=C(C1=C(C(F)(F)F)N(C2=CC=C(NC(/C(Cl)=C(Cl)/Cl)=O)C=C2)N=C1)OCC

• Molecular Formula:

  C16H11Cl3F3N3O3

• Molecular Weight:

  456.63

• Precautions:

  H302, H314

• References & Citations:

  [1]Kiyonaka S, et al. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc Natl Acad Sci U S A. 2009 Mar 31;106 (13) :5400-5.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1160514-60-2]