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Ametantrone (acetate)

CAT: 0804-HY-13550ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-13550ASize:1 Each
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Description
Ametantrone acetate (NSC 196473 acetate) is an antineoplastic drug with topoisomerase II inhibitory activity. Ametantrone acetate causes covalent cross-linking of DNA. The pharmacokinetic profile of Ametantrone acetate has been confirmed in clinical trials, and its elimination pathway in the body indicates the existence of a major metabolic pathway[1].
CAS Number
70711-40-9
Product Name Alternative
NSC 196473 (acetate) ; NSC 290813 (acetate)
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ametantrone-acetate.html
Smiles
O=C1C2=C(C(C3=C(C=CC(NCCNCCO)=C13)NCCNCCO)=O)C=CC=C2.CC(O)=O.CC(O)=O
Molecular Formula
C26H36N4O8
Molecular Weight
532.59
References & Citations
[1]Lee CH, et al. Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochem Pharmacol. 2012;83 (9) :1208-1216. |[2]Pharmacokinetics of ametantrone acetate (NSC-287513)
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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