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VU0422288

CAT: 0804-HY-110190-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-110190-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice[1][2].
CAS Number
1630936-95-6
Product Name Alternative
ML396
UNSPSC
12352005
Hazard Statement
H302, H319
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0422288.html
Purity
99.94
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
ClC(C=C(NC(C1=CC=CC=N1)=O)C=C2)=C2OC3=CC=C(Cl)C=N3
Molecular Formula
C17H11Cl2N3O2
Molecular Weight
360.19
Precautions
H302, H319
References & Citations
[1]Jalan-Sakrikar N, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5 (12) :1221-37. |[2]Gogliotti RG, et al. mGlu7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome. Sci Transl Med. 2017 Aug 16;9 (403) :eaai7459.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR4; mGluR7; mGluR8

Alternative Products

CatalogName
BA5566-10VU0422288

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