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A-381393

CAT: 0804-HY-116941-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116941-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-381393 is a potent, selective, brain penetrate dopamine D4 receptor antagonist, with Kis of 1.5, 1.9 and 1.6 nM for human dopamine D4.4, D4.2, and D4.7 receptor, respectively, >2700-fold selectivity over D1, D2, D3 and D5 dopamine receptors. A-381393 shows moderate affinity for 5-HT2A (Ki, 370 nM) [1].
CAS Number
726174-00-1
Product Name Alternative
Bisdesethylchloroquine, Bisdesethylchloroquine-d13
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/A-381393.html
Purity
99.92
Solubility
DMSO : 51.67 mg/mL (ultrasonic)
Smiles
CC1=CC=C(C=C1C)N2CCN(CC2)CC3=NC4=CC=CC=C4N3
Molecular Formula
C20H24N4
Molecular Weight
320.43
Precautions
H315, H319
References & Citations
[1]Nakane M, et al. 2-[4- (3,4-Dimethylphenyl) piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist. Neuropharmacology. 2005 Jul;49 (1) :112-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor; D3 Receptor; D4 Receptor

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