Kira8

• Description :

  Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM[1].

• CAS Number :

  [1630086-20-2]

• Product Name Alternative :

  AMG-18

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  IRE1

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/Kira8.html

• Purity :

  98.90

• Solubility :

  DMSO : 65 mg/mL (ultrasonic) |Ethanol : 76.92 mg/mL (ultrasonic; adjust pH to 5 with HCl) |H2O : 30 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)

• Smiles :

  O=S(C1=CC=CC=C1Cl)(NC2=C3C=CC(C)=C(OC4=NC=CC=C4C5=NC(N[C@@H]6CNCCC6)=NC=C5)C3=CC=C2)=O

• Molecular Formula :

  C31H29ClN6O3S

• Molecular Weight :

  601.12

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Morita S, et al. Targeting ABL-IRE1α Signaling Spares ER-Stressed Pancreatic β Cells to Reverse Autoimmune Diabetes. Cell Metab. 2017 Apr 4;25 (4) :883-897.e8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported