Arotinoid

• Description :

  Arotinoid (RO 13-6298) is a retinoid, and acts as an orally active and highly potent agonist of retinoic acid receptors (RARs) with antipsoriatic effects. Arotinoid has antipapiltoma activity with an ED50 of 0.05 mg/kg. Arotinoid can be used for the research of skin carcinomas[1][2].

• CAS Number :

  [71441-09-3]

• Product Name Alternative :

  Ro 13-6298; Arotinoid ethyl ester

• UNSPSC :

  12352005

• Target :

  RAR/RXR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/arotinoid.html

• Purity :

  99.55

• Solubility :

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  CC1(C2=CC(/C(C)=C/C3=CC=C(C(OCC)=O)C=C3)=CC=C2C(C)(C)CC1)C

• Molecular Formula :

  C26H32O2

• Molecular Weight :

  376.53

• References & Citations :

  [1]Tsambaos D, Orfanos CE. Antipsoriatic activity of a new synthetic retinoid. The arotinoid RO 13-6298. Arch Dermatol. 1983 Sep;119 (9) :746-51.|[2]Bollag W. Arotinoids. A new class of retinoids with activities in oncology and dermatology. Cancer Chemother Pharmacol. 1981;7 (1) :27-9.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported