Perospirone

CAT: 0804-HY-B0731A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0731A-01Size:5 mg
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Description
Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM) . Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].
CAS Number
[150915-41-6]
Product Name Alternative
SM-9018 (free base)
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/perospirone.html
Concentration
10mM
Purity
99.03
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3
Molecular Formula
C23H30N4O2S
Molecular Weight
426.57
References & Citations
[1]Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54 (4) :478-81.|[2]Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18 (6) :448-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
5-HT1 Receptor;5-HT2 Receptor; mLAG-3; α-1 microglobulin

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