Perospirone

• Description :

  Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM) . Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

• Product Name Alternative :

  SM-9018 (free base)

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Dopamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/perospirone.html

• Concentration :

  10mM

• Purity :

  99.03

• Solubility :

  DMSO : 5 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3

• Molecular Formula :

  C23H30N4O2S

• Molecular Weight :

  426.57

• References & Citations :

  [1]Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54 (4) :478-81.|[2]Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18 (6) :448-54.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  5-HT1 Receptor;5-HT2 Receptor; mLAG-3; α-1 microglobulin

• CAS Number :

  [150915-41-6]