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APC0576

CAT: 0804-HY-124445Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-124445Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APC0576 is an inhibitor for the activation of NF-κB signaling pathway, and inhibits the activation of NF-κB depedent gene (IC50 is 1.0 μM for β-gal) . APC0576 inhibits IL-1-induced chemokines release, and can be used in research about pathological endothelial cell activation releted diseases[1].
CAS Number
318967-58-7
UNSPSC
12352005
Target
NF-κB
Type
Reference compound
Related Pathways
NF-κB
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/apc0576.html
Smiles
O=C([C@@H]1C(C)(C1)C)NC(C=N2)=CC=C2OC(C=C3)=CC=C3NC([C@@H]4C(C)(C4)C)=O
Molecular Formula
C23H27N3O3
Molecular Weight
393.48
References & Citations
[1]Takehana K, et al., APC0576, a novel inhibitor of NF-kappaB-dependent gene activation, prevents pro-inflammatory cytokine-induced chemokine production in human endothelial cells. Biochem Biophys Res Commun. 2002 May 10;293 (3) :945-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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