1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

• CAS Number: 120693-53-0
• UNSPSC Description: 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC50s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL[1][2][3].
• Target Antigen: Acyltransferase; Angiotensin Receptor; Bacterial
• Type: Natural Products
• Related Pathways: Anti-infection;GPCR/G Protein;Metabolic Enzyme/Protease
• Applications: Metabolism-sugar/lipid metabolism
• Field of Research: Infection; Metabolic Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/1-methyl-2-4z-7z-4-7-tridecadienyl-4-1h-quinolone.html
• Solubility: 10 mM in DMSO
• Smiles: CN1C2=CC=CC=C2C(C=C1CCC/C=C\C/C=C\CCCCC)=O
• Molecular Weight: 337.50
• References & Citations: [1]Rho TC, et, al. Anti-Helicobacter pylori activity of quinolone alkaloids from Evodiae fructus. Biol Pharm Bull. 1999 Oct;22(10):1141-3.|[2]Lee HS, et, al. Inhibition of angiotensin II receptor binding by quinolone alkaloids from Evodia rutaecarpa. Phytotherapy Research. 1998 May; 12(3): 212-214.|[3]Ko JS, et, al. Quinolone alkaloids, diacylglycerol acyltransferase inhibitors from the fruits of Evodia rutaecarpa. Planta Med. 2002 Dec;68(12):1131-3.|[4]Adams M, et, al. Inhibition of leukotriene biosynthesis by quinolone alkaloids from the fruits of Evodia rutaecarpa. Planta Med. 2004 Oct;70(10):904-8.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported