(-) -Pimobendan

• Description :

  (-) -Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into erythrocytes. The clearance of (-) -pimobedan from erythrocytes is significantly lower than that of (+) -pimobedan, which is entirely due to its stereoselective distribution into erythrocytes. This stereoselective property of (-) -pimobedan may explain the phenomenon previously reported that it produces a 1.5-fold greater contractile force than the (+) -isomer in detergent-treated myocardial specimens of guinea pigs and dogs. These properties suggest that (-) -pimobedan may have unique advantages in terms of in vivo distribution and pharmacological action, which may have important implications for its clinical use.

• Product Name Alternative :

  (-) -UD-CG115

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/minus-pimobendan.html

• Smiles :

  O=C1CC(C)C(C2=CC=C3C(N=C(C4=CC=C(OC)C=C4)N3)=C2)=NN1.[Rotation(-)]

• Molecular Formula :

  C19H18N4O2

• Molecular Weight :

  334.37

• References & Citations :

  [1]Plasma and red blood cell pharmacokinetics of pimobendan enantiomers in healthy Chinese

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [118428-37-8]