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(-) -Pimobendan

CAT: 0804-HY-B0204BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-B0204BSize:1 Each
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Description
(-) -Pimobedan is an isomer of pimobedan. It has the property of stereoselective partitioning or distribution into erythrocytes. The clearance of (-) -pimobedan from erythrocytes is significantly lower than that of (+) -pimobedan, which is entirely due to its stereoselective distribution into erythrocytes. This stereoselective property of (-) -pimobedan may explain the phenomenon previously reported that it produces a 1.5-fold greater contractile force than the (+) -isomer in detergent-treated myocardial specimens of guinea pigs and dogs. These properties suggest that (-) -pimobedan may have unique advantages in terms of in vivo distribution and pharmacological action, which may have important implications for its clinical use.
CAS Number
118428-37-8
Product Name Alternative
(-) -UD-CG115
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/minus-pimobendan.html
Smiles
O=C1CC(C)C(C2=CC=C3C(N=C(C4=CC=C(OC)C=C4)N3)=C2)=NN1.[Rotation(-)]
Molecular Formula
C19H18N4O2
Molecular Weight
334.37
References & Citations
[1]Plasma and red blood cell pharmacokinetics of pimobendan enantiomers in healthy Chinese
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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