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Carisbamate

CAT: 0804-HY-14948-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14948-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy[1][2][3].
CAS Number
194085-75-1
Product Name Alternative
RWJ-333369
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/carisbamate.html
Purity
98.75
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC(OC[C@H](C1=CC=CC=C1Cl)O)=O
Molecular Formula
C9H10ClNO3
Molecular Weight
215.64
Precautions
H302, H315, H319, H335
References & Citations
[1]Deshpande LS, et al. Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons. Epilepsia. 2008 Oct;49 (10) :1795-802. |[2]François J, et al. Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS. Epilepsia. 2008 Mar;49 (3) :393-9. |[3]Novak GP, et al. Carisbamate (RWJ-333369) . Neurotherapeutics. 2007 Jan;4 (1) :106-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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