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Levomilnacipran

CAT: 0804-HY-14794ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14794ASize:1 Each
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Description
Levomilnacipran ((1S,2R) -Milnacipran) is the enantiomer of Milnacipran and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression[1][2][3][4].
CAS Number
96847-54-0
Product Name Alternative
(1S,2R) -Milnacipran; F2695
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Akt; mTOR; P-glycoprotein; PI3K; Serotonin Transporter; Trk Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/levomilnacipran.html
Solubility
10 mM in DMSO
Smiles
O=C(N(CC)CC)[C@@]1([C@@H](C1)CN)C2=CC=CC=C2
Molecular Formula
C15H22N2O
Molecular Weight
246.35
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Asnis GM, et al. Levomilnacipran for the treatment of major depressive disorder: a review. Neuropsychiatr Dis Treat. 2015 Jan 9;11:125-35.|[2]Bundgaard C, et al. P-glycoprotein differentially affects escitalopram, levomilnacipran, vilazodone and vortioxetine transport at the mouse blood-brain barrier in vivo. Neuropharmacology. 2016 Apr;103:104-11.|[3]Wu Y, et al. Levomilnacipran Improves Lipopolysaccharide-Induced Dysregulation of Synaptic Plasticity and Depression-Like Behaviors via Activating BDNF/TrkB Mediated PI3K/Akt/mTOR Signaling Pathway. Mol Neurobiol. 2024 Jul;61 (7) :4102-4115.|[4]Auclair AL, et al. Levomilnacipran (F2695), a norepinephrine-preferring SNRI: profile in vitro and in models of depression and anxiety. Neuropharmacology. 2013 Jul;70:338-47.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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