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SMU127

CAT: 0804-HY-122566Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-122566Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer. It induces NF-κB signaling in cells expressing human TLR2 (EC50=0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM. In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.
CAS Number
903864-87-9
Product Name Alternative
ZINC666243
UNSPSC
12352005
Target
TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/smu127.html
Smiles
O=C(C1=C(NC(N2CCN(C)CC2)=O)SC3=C1CCC3)OCC
Molecular Formula
C16H23N3O3S
Molecular Weight
337.44
References & Citations
[1]Chen, et al. Structure-based discovery of a specific TLR1-TLR2 small molecule agonist from the ZINC drug library database. Chem. Commun. (Camb.) 54 (81), 11411-11414 (2018) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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